How-To Video: Installing GastroPlus ® Standalone Installation.Our software runs on Mac operating systems with Windows virtualization. Because they incorporate a much larger set of differential equations, PBPK simulations typically require about 5-10 seconds, but can be longer. On a 2.4 GHz Pentium 4 computer with 512 MB of RAM, our software executes a typical 24-hour single simulation in less than one second with standard compartmental pharmacokinetics. Most modern Pentium machines with speeds of 1 GHz or faster should be able to run our software however, simulation software is computationally intensive and always benefits from greater speed and memory. A minimum of 1 GB of RAM is recommended for optimal performance. Our software is designed to run on Pentium-class Windows 11 (64-bit), Windows 10 (64-bit) and Windows 8 (64-bit) computers or Windows Server 2019 (64-bit), Windows Server 2016 (64-bit), and Windows Server 20 R2 (64-bit). However, the jar file – C:\Program Files (x86)\FlexNet Publisher License Server Manager\examples\alerter\lib\Log4j-1.2.8.jar – is not required and may be removed. This version of log4j is not affected by any of the listed vulnerabilities. An older version of log4j (version 1.2.8) is installed with the Flexera License Server that is used to license our products. Regarding the log4j vulnerabilities described in CVE-2021-44228, CVE-2021-45046, and CVE-2021-45105: Our products do not require Log4j and are not vulnerable to the exploits.
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